How do I kill a Big Sister on the Hard Difficulty (the Hardest) on Bioshock 2 without dying?
Question: Please, need help. Just got all achievements for BS, now need for BS2. Starting with Big Brass Balls.
Answer: If you have the bees splice fully upgraded use that, forgot what is was called. But that usually does significant damage, and if you can manage use the drill upgraded to where as you drill it gives you health

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Our simple damage formula makes it easy to determine that he'll take 1/X times as much damage from attacks as the fighter, so he'll be able to withstand X percent as much punishment before dying. The defense values on ranger and mage armor were ...
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